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目的 :探讨糖耐量减低 (impairedglucosetolerance ,IGT)患者胰岛素抵抗情况 ,胰岛素分泌功能及相关代谢指标的改变。方法 :对 4 8名糖耐量正常 (normalglucosetolerance ,NGT)者 (NGT组 )和 75例IGT患者 (IGT组 )行口服葡萄糖耐量试验和胰岛素释放试验 ,并测定其血压、体重指数、血脂、尿酸 ,计算胰岛素敏感指数 (insulinsensitivityindex ,ISI)及早期胰岛素分泌指数。 结果 :与NGT组相比 ,IGT组的收缩压、体重指数、甘油三酯、LDL C、尿酸、空腹胰岛素、服糖后 2小时及 3小时胰岛素水平升高 ,两组比较差异均有统计学意义 ,P <0 0 5～P <0 0 1;而ISI、早期胰岛素分泌指数、HDL C降低 ,两组比较差异均有统计学意义 ,P <0 0 5～P <0 0 1。结论 :IGT患者存在明显胰岛素抵抗、胰岛B细胞功能异常及多种代谢异常 ,提示及早干预治疗 ,对减少糖尿病的发生 ,阻止或延缓大血管病变具有重要的意义。
Objective: To investigate the changes of insulin resistance, insulin secretion and related metabolic indexes in patients with impaired glucosetolerance (IGT). Methods: The oral glucose tolerance test and insulin release test were performed in 48 normal glucose tolerance group (NGT) and 75 IGT patients (IGT group). The blood pressure, body mass index, blood lipid, uric acid, Insulin sensitivity index (ISI) and early insulin secretion index were calculated. Results: Compared with NGT group, systolic blood pressure, body mass index, triglyceride, LDL C, uric acid, fasting insulin and insulin levels at 2h and 3h after IGT were significantly higher in IGT group Significance, P <0 05 ~ P 0 01; but ISI, early insulin secretion index, HDL C decreased, the difference between the two groups were statistically significant, P <0 05 ~ P 0 01. Conclusion: There are obvious insulin resistance, islet B cell dysfunction and a variety of metabolic abnormalities in patients with IGT, suggesting that early intervention treatment is of great significance to reduce the occurrence of diabetes and prevent or delay the progression of macrovascular disease.