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阿司匹林(ASA)是第一种用动力学证明具有首过作用的药物,有人报道,它在人和狗身上的肠、肝首过作用。作者用大白鼠来评论ASA的不同给药途径(静注、口服或门静脉给药)对它的动力学影响并比较肠、肝首过作用。实验用雄性大白鼠,按常规法用聚硅树脂管插入右颈静脉内,插管后两天进行大剂量静注或口服实验。以4只大白鼠一组,不经麻醉,以10mg/kg的ASA经插管或胃管给药,然后分别关在代谢笼里收集尿和粪。在4、8、24和48小时收集尿,逐日收集粪。样品保存于零度。另一组(n=6)按常规插管和未经麻醉的大白鼠,照上述相同的剂量给药,
Aspirin (ASA) was the first pharmacologically proven first-mover drug and it was reported that it had the first pass in the intestine and liver in humans and dogs. The authors used rats to comment on the kinetic effects of different routes of administration of ASA (intravenous, oral or intravenous administration) and to compare the first pass of the intestine and the liver. Experimental male rats, according to the conventional method with silicone tube inserted into the right jugular vein, two days after intubation high-dose intravenous or oral experiments. A group of 4 rats were anesthetized, administered with ASA at 10 mg / kg via cannula or gastric tube, and then placed in metabolic cages to collect urine and feces respectively. Urine was collected at 4, 8, 24 and 48 hours, and feces were collected daily. Samples are stored at zero degrees. The other group (n = 6) was routinely intubated and non-anesthetized rats administered the same dose as above,