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褪黑素是一种主要由松果体合成的激素。它的合成和分泌受到光强度的调节,并且其分泌量随着年龄的增长而逐渐减少。研究发现,褪黑素有调节睡眠周期、抗氧化和抗炎、调节脂质和葡萄糖代谢的功能。近年有研究表明,褪黑素在高血压、心肌缺血/再灌注损伤(MI/RI)、肺动脉高压、心肌慢性间歇性低氧损伤、血管疾病以及心脏瓣膜疾病等多种心血管疾病中起着重要作用。本文就褪黑素与心血管疾病关系的研究进展做一简要阐述。
Melatonin is a hormone synthesized mainly by the pineal gland. Its synthesis and secretion are regulated by light intensity, and its secretion gradually decreases with age. The study found that melatonin has the function of regulating the sleep cycle, anti-oxidation and anti-inflammatory, regulating lipid and glucose metabolism. Recent studies have shown that melatonin plays a role in a variety of cardiovascular diseases such as hypertension, myocardial ischemia / reperfusion (MI / RI), pulmonary hypertension, chronic intermittent hypoxic myocardial injury, vascular diseases and valvular heart disease An important role. This article gives a brief exposition on the research progress of the relationship between melatonin and cardiovascular diseases.