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头孢甲肝(cefmenoxime,CMX)是具有广谱抗菌作用的第三代头孢菌素,作者研究了CMX在接受胆囊切除术病人体内的动态变化,探讨了药物浓度与致病菌敏感性的关系。病例:胆总管结石4例,胆囊结石21例、胆囊癌1例、胆息肉1例、共27例,年龄27～81岁,男性11例,女性16例。所有病例均按外科原则施行胆囊摘除术。方法:将病例分为五组,分别按术前5、3、2、1、0小时给药、CMX1克溶于100ml葡萄糖注射液中,于1小时内静滴结束,给药
Cefmenoxime (CMX) is a third generation cephalosporin with broad-spectrum antibacterial activity. The authors studied the dynamic changes of CMX in patients undergoing cholecystectomy and discussed the relationship between drug concentration and pathogenic bacteria sensitivity. Cases: common bile duct stones in 4 cases, 21 cases of gallbladder stones, gallbladder carcinoma in 1 cases, gallbladder in 1 case, a total of 27 cases, aged 27 to 81 years, 11 males and 16 females. All cases undergone surgical excision of gallbladder. Methods: The patients were divided into five groups, respectively, according to 5,3,2,1,0 hours before surgery, CMX1 grams dissolved in 100ml glucose injection, intravenous infusion within 1 hour, the administration