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目的：探讨幽门螺杆菌（Hp）感染对上消化道疾病中胃粘膜病理改变的影响。方法：对602例患者胃粘膜标本分别做尿素酶试验和美蓝染色检测Hp，病理活检HE染色观察胃粘膜病理改变，并观察伴有萎缩、肠化和腺上皮不典型增生的程度。结果：Hp检出率较低，为48．0％。慢性活动性胃炎Hp感染率最高，为83．7％。Hp感染与慢性活动性胃炎、消化性溃疡、重度萎缩性胃炎和腺上皮不典型增生关系密切，与无Hp感染差异有显著性（P＜0．05）。结论：Hp感染是上消化道疾病的重要致病因素之一，Hp感染引起胃粘膜癌前期病变，可能是胃病的致病因素之一。
Objective: To investigate the effect of Helicobacter pylori (Hp) infection on pathological changes of gastric mucosa in upper gastrointestinal diseases. Methods: Gastric mucosa samples of 602 patients were tested for urease and methylene blue staining respectively. The pathological changes of gastric mucosa were observed by pathological biopsy, and the degree of atypia hyperplasia associated with atrophy, intestinal metaplasia and glandular epithelium were observed. Results: The detection rate of Hp was lower at 48.0%. Chronic active gastritis Hp infection rate was the highest, 83.7%. Hp infection was closely related to chronic active gastritis, peptic ulcer, severe atrophic gastritis, and atypical hyperplasia of glandular epithelium. There was a significant difference between Hp infection and non-Hp infection (P <0.05). Conclusion: Hp infection is one of the most important risk factors of upper gastrointestinal diseases. Hp infection causes precancerous lesions of gastric mucosa and may be one of the causative agents of gastric diseases.