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目的:观察冠心病患者血清载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)与血浆D-二聚体(DD)水平的变化特点,并探讨它们之间的关系。方法:对124例CHD患者和26例正常人采用免疫散射比浊法测定ApoAI、ApoB浓度,ELISA法测定DD水平。结果:不同类型的冠心病患者中,其DD水平和Apo浓度有所不同(F=44.2,126.3,29.6,P均<0.01),其中急性心肌梗死(AMI)和不稳定性心绞痛(UAP)组患者ApoB浓度、DD水平均显著高于对照组(P<0.01);陈旧性心肌梗死(OMI)和稳定性心绞痛(SAP)组患者ApoB浓度高于对照组,ApoAI浓度低于对照组(P<0.01),但DD水平无改变(P>0.05)。124例冠心病患者相关分析显示:ApoB与DD呈显著正相关,ApoAI与DD呈显著负相关(P<0.001)。结论:冠心病患者存在载脂蛋白代谢异常,AMI、UAP组患者DD水平增高,且载脂蛋白与DD水平有密切关系。
Objective: To observe the changes of serum apolipoprotein AI (ApoAI), apolipoprotein B (ApoB) and plasma D-dimer (DD) in patients with coronary heart disease and to explore the relationship between them. Methods: The levels of ApoAI and ApoB in 124 cases of CHD and 26 normal subjects were determined by immune nephelometry. The level of DD was measured by ELISA. Results: The levels of DD and Apo in different types of patients with coronary heart disease were different (F = 44.2,126.3,29.6, P <0.01), and AMI and UAP groups (P <0.01). The concentrations of ApoB in patients with old myocardial infarction (OMI) and stable angina pectoris (SAP) were higher than those in the control group, and the concentrations of ApoAI were lower than those in the control group (P < 0.01), but no change in DD level (P> 0.05). Correlation analysis of 124 patients with coronary heart disease showed that ApoB was positively correlated with DD, and ApoAI was significantly negative correlated with DD (P <0.001). Conclusion: There is abnormal apolipoprotein metabolism in patients with coronary heart disease. DD levels are increased in patients with AMI and UAP, and apolipoproteins are closely related to DD.