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氨羟苄青霉素(Amoxycillin)是一种新的半合成青霉素,和氨苄青霉素一样是广谱抗菌素,但血清浓度为后者的两倍。将200例血培养证实为伤寒的儿童随机分为两组,每组100例。氨羟苄青霉素治疗组(甲组):用药为2克/日,氯霉素治疗组(乙组):按50毫克/公斤/日用药;均服21天。年龄、营养状况、病程,病情较重以及并发症等两组大致相同。治疗结果:临床症状在5天内改善者甲组为82％,乙组仅为56％,差异非常显著(P<0.001)。平均8天内退热者甲组中占85％,乙组中仅占68％,差异显著(P<0.01)。在治疗前,甲组和乙组中分别有6例、2例的中性粒细胞数低于2000,但治疗期间均升至正常。甲组有14％患儿在治疗初期中性粒细胞降低到2000以下,但继续用药后均恢复正常。在服药72
Amoxycillin, a new semi-synthetic penicillin, is as broad-spectrum antibiotic as ampicillin but at twice the serum concentration. 200 cases of blood culture confirmed typhoid children were randomly divided into two groups of 100 cases. Ampicillin treatment group (Group A): medication for 2 g / day, chloramphenicol treatment group (B): 50 mg / kg / day medication; were served for 21 days. Age, nutritional status, duration, serious condition and complications were similar in two groups. Treatment outcome: Clinical symptoms were improved in 5 days in group A as 82% and in group B as only 56%, with a significant difference (P <0.001). In the first 8 days, the rate of fever in group A was 85%, in group B only 68%, the difference was significant (P <0.01). Before treatment, group A and group B, respectively, 6 cases, 2 cases of neutrophils less than 2000, but during treatment rose to normal. A group of 14% of children in the initial treatment of neutrophils decreased to below 2000, but continued to return to normal after treatment. Medication 72