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单用α-干扰素治疗毛细胞白血病(HCL)最初有效,但易产生抗体或耐药.作者用小剂量2~1-去氧助间型霉素(2~1-Deoxycoformyoin, DCF)治疗对α-干扰素耐药的HCL患者.获得满意疗效.DCF的剂量为4mg/m~2.隔周一次,共12次.完全缓解(CR)的标准是外周血,骨髓抽吸和骨髓活检至少连续2次检验未见毛细胞,且外周血象恢复正常.结果:11例HCL患者中男10例,女1例,中位年龄53岁,其中6例作过脾切
Alpha-interferon treatment of hairy cell leukemia (HCL) initially effective, but easy to produce antibodies or drug resistance. The author with a small dose of 2 ~ 1-deoxy moxifloxacin (DCF) treatment of interferon-resistant HCL patients with satisfactory results. The dose of DCF is 4 mg / m 2 once every other week for a total of 12 times.The standard of complete remission (CR) is peripheral blood, bone marrow aspiration and bone marrow biopsy No hair cells were found in 2 consecutive tests and peripheral blood returned to normal.Results: Among 11 HCL patients, 10 were male and 1 female, with a median age of 53 years and 6 of them were splenectomized