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将7,12-二甲基苯并蒽涂布在小鼠背部的皮肤上以诱导产生乳头状瘤,探讨了小柴胡汤对鳞状细胞乳头状瘤的形成和生长的影响。结果表明,长期经口投与小柴胡汤,可明显降低琥珀酸脱氢酶(细胞存活的标志)和胸苷酸合成酶(在DNA从头合成过程中起重
7,12-Dimethylbenzofluorene was applied to the skin of mice’s back to induce papilloma. The effect of Xiaochaihu Decoction on the formation and growth of squamous cell papilloma was investigated. The results showed that long-term oral administration of Xiaochaihu Decoction can significantly reduce succinate dehydrogenase (a marker of cell survival) and thymidylate synthase (uplift during DNA de novo synthesis).