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隐睾症是人类男性生殖系统先天性畸形最常见的疾病之一,但其基因水平的发病机制仍然不清。胰岛素样激素3(INSL-3,insu lin like factor 3)与影响睾丸下降的G蛋白偶联受体(GREAT/LGR8,G-protein-coupled receptor affecting testis descent/leucine-rich repeat-contain ing G protein-coupled receptor8)是普遍认为的导致人类隐睾症的两个主要因素,但它们单独不能说明隐睾症的直接原因,对于INSL-3与GREAT/LGR8在人类隐睾症中的协同作用,需要对二者的基因变异进行更加深入的研究和探索。
Cryptorchidism is one of the most common diseases of congenital malformations of human male reproductive system, but the pathogenesis of its genetic level remains unclear. Insulin-like hormone 3 (INSL-3, Insulin-like factor 3) and G-protein coupled receptors (GREAT / LGR8, G-protein-coupled receptor affecting testis descent / leucine-rich repeat- -coupled receptor8) are two of the most commonly recognized causes of cryptorchidism in humans but they alone can not account for the direct cause of cryptorchidism and require a synergistic effect of INSL-3 and GREAT / LGR8 in human cryptorchidism On the two genetic variation more in-depth research and exploration.