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目的探讨降钙素原(PCT)指导下抗感染措施对呼吸机相关性肺炎(VAP)患者抗菌素使用强度的影响。方法采用随机数字表法将74例VAP患者分为两组,观察组患者在PCT指导下进行抗生素治疗,对照组患者按常规方法行抗生素治疗。结果①治疗前,两组患者白细胞计数(WBC)、中性粒细胞比值(NEU)、C反应蛋白(CRP)、临床肺部感染评分(CPIS)相比差异无统计学意义(P>0.05)。治疗后,两组患者上述指标均显著下降(P<0.05),而两组间上述指标相比差异无统计学意义(P>0.05)。②两组患者热退正常天数相比差异无统计学意义(P>0.05)。③观察组抗生素使用率及使用时间均显著低于对照组,差异有统计学意义(P<0.05)。结论 PCT指导下抗感染措施治疗VAP患者可以取得良好的疗效,还可降低抗生素的使用时间及使用率,值得临床推广应用。
Objective To investigate the effect of anti-infective measures under the guidance of procalcitonin (PCT) on the antibiotic use of patients with ventilator-associated pneumonia (VAP). Methods 74 cases of VAP patients were divided into two groups by random number table method. Patients in the observation group were treated with antibiotics under the guidance of PCT. The patients in the control group were treated with antibiotics according to the routine method. Results ① There were no significant differences in WBC, NEU, CRP and CPIS between the two groups before treatment (P> 0.05) . After treatment, the above indexes of both groups were significantly decreased (P <0.05), but there was no significant difference between the two groups (P> 0.05). ② There was no significant difference in the number of normal days between two groups (P> 0.05). ③ The observation group antibiotic use rate and the use of time were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Anti-infectives under the guidance of PCT can be used to treat VAP patients with good curative effect. It can also reduce the use of antibiotics and the rate of use, worthy of clinical application.