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目的观察急性运动对血压达标高血压患者循环内皮微颗粒(EMPs)水平的影响。方法入选血压控制达标的男性高血压患者14例[高血压组,年龄(56.4±5.0)岁]及男性正常血压志愿者12人[对照组,年龄(55.3±7.2)岁],流式细胞术检测循环EMPs水平。采用改良的Bruce’s运动方案,高血压组进行单次中等强度有氧运动,持续30min,观察运动前后循环EMPs水平的变化。结果高血压组和对照组之间的血压水平差异无统计学意义(P>0.05);与对照组比较,高血压组循环EMPs水平明显升高[(1842.4±308.3)比(922.5±136.4)个/μL,P<0.01]。与运动前比较,高血压组运动后循环EMPs水平降低[(1668.8±264.5)比(1842.4±308.3)个/μL,P<0.05]。结论血压达标高血压患者循环EMPs水平高于正常血压志愿者,运动后循环EMPs水平较运动前降低,提示运动可进一步改善药物控制达标的高血压患者受损的血管内皮功能。
Objective To observe the effect of acute exercise on circulating endothelial micro-particles (EMPs) in patients with blood pressure-induced hypertension. METHODS: Forty male patients with hypertension (56.4 ± 5.0 years old) and 12 normal volunteers (control group, age 55.3 ± 7.2 years) were enrolled in this study. Blood pressure was controlled by flow cytometry Detection of circulating EMPs levels. The modified Bruce’s exercise regimen was used. The patients in the hypertension group were subjected to a single moderate-intensity aerobic exercise for 30 minutes. The changes of circulating EMPs before and after exercise were observed. Results There was no significant difference in blood pressure levels between hypertension group and control group (P> 0.05). Compared with control group, the levels of circulating EMPs in hypertensive group were significantly higher than those in control group [(1842.4 ± 308.3) vs (922.5 ± 136.4) /μL, P <0.01]. Compared with those before exercise, the levels of circulating EMPs in the hypertension group decreased (1668.8 ± 264.5) (1842.4 ± 308.3) / μL, P <0.05). Conclusions Circulating EMPs in hypertensive patients with blood pressure elevation are higher than those in normal blood pressure patients. Circulating EMPs level after exercise is lower than that before exercise, suggesting that exercise may further improve the impaired endothelial function of hypertensive patients.