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目的观察贝那普利联合金水宝治疗糖尿病肾病的临床疗效。方法将60例早期糖尿病肾病患者随机分为3组(每组20例):贝那普利组(贝那普利10 mg,每天1次),金水宝组(金水宝3粒,每天3次),贝那普利联合金水宝组(贝那普利10 mg,每天1次+金水宝3粒,每天3次),均治疗6个月。治疗前后分别检测3组24 h尿蛋白定量、血肌酐、血尿素氮、尿微量白蛋白及尿蛋白肌酐比值。结果 3组患者药物治疗后24 h尿蛋白定量、血肌酐、血尿素氮、尿蛋白肌酐比值较治疗前均下降(P<0.05)。贝那普利联合金水宝组尿微量白蛋白降低45.8%,尿蛋白肌酐比值降低31.8%,24 h尿蛋白定量降低45.8%,血尿素氮降低20.5%,血肌酐降低24.1%。结论贝那普利联合金水宝治疗对降低尿蛋白定量,改善肾功能的疗效更明显,临床未发现明显药物不良反应。
Objective To observe the clinical efficacy of benazepril combined with Jinshuibao in the treatment of diabetic nephropathy. Methods Sixty patients with early diabetic nephropathy were randomly divided into 3 groups (20 in each group): benazepril group (benazepril 10 mg once daily), Jin Shui Bao group ), Benazepril combined with Jinshuibao group (benazepril 10 mg, 1 day + 3 tablets of Jin Shui Bao, 3 times a day) for 6 months. Before and after treatment, the 24-hour urinary protein, serum creatinine, blood urea nitrogen, urine microalbuminuria and urinary protein creatinine were measured in three groups respectively. Results The urinary protein, serum creatinine, blood urea nitrogen and urinary protein creatinine in 24 hours after treatment in 3 groups were significantly lower than those before treatment (P <0.05). Benazepril combined with Jinshuibao group decreased urinary albumin by 45.8%, urine creatinine ratio decreased by 31.8%, 24 h urine protein reduced by 45.8%, blood urea nitrogen decreased by 20.5% and serum creatinine decreased by 24.1%. Conclusion The combination of benazepril and Jinshuibao has obvious curative effect on reducing urinary protein and improving renal function. No obvious clinical adverse reactions have been found.