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目的观察参芪扶正注射液对非小细胞肺癌(NSCLC)化疗患者生存质量的影响。方法采用多中心、随机、空白对照的研究方法,在全国11个分中心选取有明确病理诊断的232例NSCLC化疗患者,随机分为化疗组与参芪扶正注射液加化疗组。对两组患者的生存质量评价主要采用国际公认的欧洲癌症研究与治疗组织的生命质量核心量表(EORTC QLQ-C30)与癌症患者生活功能指标量表(FLIC)。结果参芪扶正注射液合并化疗可以明显改善NSCLC患者的躯体、心理、社会等多方面的生存质量,增加患者的体重,改善患者的神疲乏力、少气懒言、疼痛、胸胁胀满、痰多、咳嗽、面色恍白等临床症状,调节患者的免疫功能,还有提高肿瘤化疗客观有效率的趋势。参芪扶正注射液用药安全,无严重的不良反应。结论参芪扶正注射液可作为NSCLC化疗患者辅助用药,并能提高患者的生存质量。
Objective To observe the effect of Shenqi Fuzheng injection on the quality of life in patients with non-small cell lung cancer (NSCLC) chemotherapy. Methods A total of 232 NSCLC patients with definite pathological diagnosis were selected from 11 sub-centers in our country. The patients were randomly divided into chemotherapy group and Shenqi Fuzheng injection plus chemotherapy group. The quality of life assessment of both groups was based on the internationally accepted European Organization for Research and Treatment of Quality of Life Core Scale (EORTC QLQ-C30) and the Cancer Patients Living Function Scale (FLIC). Results Shenqi Fuzheng injection combined with chemotherapy can significantly improve the quality of life of somatic, psychological, social and other aspects of patients with NSCLC, increase the patient’s weight, improve the patient’s Shenpi fatigue, less gas lazy words, pain, chest Xiongxie fullness, Phlegm, cough, pale and other clinical symptoms, regulate the immune function of patients, as well as improve the objective and efficient chemotherapy trend. Shenqi Fuzheng injection medication safety, no serious adverse reactions. Conclusion Shenqi Fuzheng injection can be used as adjunctive therapy in patients with NSCLC chemotherapy and can improve the quality of life of patients.