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目的：探讨根治切除术联合抗病毒治疗肝癌合并乙型肝炎病毒感染患者的临床疗效。方法将72例行根治术治疗的肝癌合并乙型肝炎病毒感染患者按随机数字表法分为两组，每组36例。两组均行根治切除术，观察组联合抗病毒治疗，对照组行常规护肝、抗感染和外科营养治疗，观察住院全程。于治疗前后比较两组患者的肝功能和病毒学指标，并统计并发症发生状况。结果治疗后观察组谷丙转氨酶及乙型肝炎病毒的脱氧核糖核酸水平较治疗前显著降低（P＜0．01），对照组谷丙转氨酶、血清白蛋白及前白蛋白水平较治疗前显著降低（P＜0．01）；治疗前两组各项指标水平比较差异无显著性（P＞0．05），治疗后观察组各项指标水平均显著优于对照组（P＜0．01）。观察组并发症发生率为8．3％，对照组为33．3％，观察组显著低于对照组（P＜0．01）。结论根治切除术联合抗病毒治疗能显著改善肝癌合并乙型肝炎病毒感染患者的肝功能和病毒学指标，疗效显著，优于单用根治切除术治疗。“,”Objective To explore the efficacy of radical excision plus antiviral therapy for hepatic carcino‐ma (HC) concurrent with hepatitis b virus (HBV)infection (HBVI) .Methods Seventy‐two HC patients concurrent with HBV infection undergoing radical correction were randomly assigned to two groups of 36 each .Both groups received radical excision ,observation group was plus antiviral therapy ,control group did routine liver protection ,anti‐infection and surgical nutritional therapy ,and their w hole courses of hos‐pitalization observed .Liver functions and virology indexes were compared between two groups and compli‐cations added up .Results After the treatment glutamic‐pyruvic transaminase (GPT ) and HBV‐DNA lev‐els lowered more significantly in observation group (P<0 .01) ,so did GPT ,serum albumin (ALB) and prealbumin in control group (P0 .05) ,after treatment all indexes levels were significantly better in observation than in control group (P<0 .01) .The incidence of complications was 8 .3% in observation and 33 .3% in control group ,the former significantly lower than the latter (P< 0 .01) .Conclusion Radical excision plus antiviral therapy could improve liver functions and virology indexes of HC patients with HBV infection and has an evident effect compared single radical resection .