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目的:探讨自由基清除剂(丹参注射液)在小儿肺炎治疗中的临床效果。方法:选取2009年1月～2011年1月于该院进行治疗的90例小儿肺炎患者为研究对象,将其随机分为对照组(常规治疗组)45例和观察组(常规治疗联合自由基清除剂组)45例,后将两组患者的治疗总有效率、各项症状、体征改善时间、不良反应发生率及治疗前、治疗后1天、3天血清CRP、TNF-α、NO、SOD、MDA水平进行统计及比较。结果:观察组的治疗总有效率高于对照组,各项症状、体征改善时间短于对照组,治疗后1天及3天的血清CRP、TNF-α、NO、MDA水平低于对照组,血清SOD水平高于对照组,P值均<0.05,均有统计学差异,而两组不良反应发生率无统计学差异,P>0.05。结论:自由基清除剂在小儿肺炎治疗中的临床效果较好,安全性较高,显效快,综合优势突出。
Objective: To investigate the clinical effect of free radical scavenger (Danshen injection) in the treatment of pediatric pneumonia. Methods: Ninety children with pneumonia treated in our hospital from January 2009 to January 2011 were selected as study subjects and randomly divided into control group (45 cases) and observation group (conventional treatment combined with free radical Scavenger group). The total effective rate, the symptoms, the time of symptom improvement, the incidence of adverse reactions and the levels of CRP, TNF-α, NO, SOD and MDA levels were statistically compared. Results: The total effective rate of observation group was higher than that of control group, and the improvement time of symptoms and signs was shorter than that of control group. The levels of CRP, TNF-α, NO and MDA in serum of 1 and 3 days after treatment were lower than those of control group, The level of serum SOD was higher than that of the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: Free radical scavenger in children with pneumonia in the treatment of better clinical results, higher safety, effective fast, the overall advantages of outstanding.