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目的探讨间苯三酚在活跃期用于改善宫颈扩张条件、促进产程进展的疗效及安全性。方法将初产妇、产程处于活跃期内宫口开大≥3 cm伴宫颈水肿者100例,随机分为间苯三酚组58例,地西泮组42例。记录2组产妇的产程情况以及用药后对母儿的影响。结果间苯三酚组用药至宫口开全的时间及宫口的扩张速度较地西泮组差异有统计学意义(P<0.05),两组分娩方式比较差异有统计学意义(P<0.05),用药后宫颈水肿消失率、总产程、第二产程时间及产后2 h出血量差异无统计学意义(P>0.05)。间苯三酚组用药后母儿无不良反应。地西泮组用药后,部分产妇出现头晕、乏力、胎心率变异减少。结论间苯三酚能改善宫颈扩张条件,促进产程进展,且对母儿无明显不良影响。
Objective To investigate the efficacy and safety of phloroglucinol in the active stage for improving cervical dilation conditions and promoting the progress of labor. Methods 100 cases of primipara and labor during the active period were enrolled in this study. All patients were randomly divided into three groups: 58 cases in phloroglucinol group and 42 cases in diazepam group. Record two groups of maternal labor process and the impact on the mother and child after treatment. Results Compared with diazepam group, the time of application of phloroglucinol to cervix and the rate of uterine cervix expansion were significantly different (P <0.05), and there was significant difference in the mode of delivery between the two groups (P <0.05 ), After treatment, the disappearance of cervical edema, total labor, the second stage of labor and postpartum 2 h bleeding was no significant difference (P> 0.05). Phloroglucinol medication no adverse reactions after the mother. Diazepam group medication, some mothers dizziness, fatigue, reduced fetal heart rate variability. Conclusion Phloroglucinol can improve cervical dilation conditions and promote the progress of labor, and no significant adverse effects on the mother and child.