应用牛磺胆酸钠诱发大鼠急性出血坏死性胰腺炎并发肺损伤模型，动态观察血中ＴＸＢ＿２、６－酮－ＰＧＦ＿１ａ及ＬＰＯ含量变化并观察川芎嗪的影响。结果表明：随着肺损伤程度加重，血浆ＴＸＢ＿２含量、ＴＸＢ＿２／６－酮－ＰＧＦ＿１ａ比值，ＬＰＯ含量渐增高，肺系数值也增加；川芎嗪能显著降低ＴＸＢ＿２和ＬＰＯ含量，稳定ＴＸＢ＿２／６－酮－ＰＧＦ＿１ａ比值，降低肺系数值，改善肺组织病理形态变化，从而提高存活率。 The rat models of acute hemorrhagic necrotizing pancreatitis complicated by lung injury were induced by sodium taurocholate. The changes of blood TXB_2, 6-keto-PGF_1a and LPO levels were observed dynamically and the effects of tetramethylpyrazine were observed. The results showed that with the severity of lung injury, plasma TXB_2 content, TXB_2/6-keto-PGF_1a ratio, LPO content increased, and lung coefficient value increased; Tetramethylpyrazine could significantly reduce TXB_2 and LPO content and stabilized TXB_2/6-ketone. The ratio of -PGF_1a decreases the lung coefficient value and improves the pathological changes of the lung tissue, thereby increasing the survival rate.