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本文报道锌预处理的雄性Sprague-Dawley大鼠降低镉的致死性和肝毒性的作用。大鼠在给予镉之前48和24小时,经皮下注射生理盐水(2ml/kg)或锌(12mgZn/kg)进行预处理,然后静脉注射镉的致死剂量4.0 mgCd/kg或镉的非致死剂量3.5mgcd/kg(7μCi~(109)Cd/mgCd),观察动物的致死率、主要器官的镉分布、血浆中酶的活性及组织形态。结果生理盐水-镉(4.0mgCd/kg)组的大鼠在给镉后10～20小时之间全部死亡,而锌-镉(4.0mgCd/kg)组的动物无死亡现象。
This article reports the role of zinc-pretreated male Sprague-Dawley rats in reducing lethality and hepatotoxicity of cadmium. Rats were pretreated with saline (2 ml / kg) or zinc (12 mg Zn / kg) 48 and 24 hours prior to the administration of cadmium followed by IV lethal dose of cadmium 4.0 mg Cd / kg or non-lethal dose of cadmium 3.5 mgcd / kg (7μCi ~ (109) Cd / mgCd) were used to observe the lethality of animals, cadmium distribution in major organs, enzyme activity in plasma and histomorphology. Results Rats in the saline-cadmium group (4.0 mg Cd / kg) all died between 10 and 20 hours after cadmium exposure, while animals in the zinc-cadmium (4.0 mg Cd / kg) group did not die.