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目的 探讨人宫颈中bcl- 2基因表达的改变与其临床意义。方法 对 149例宫颈组织采用免疫组化ABC法检测bcl- 2基因蛋白的表达 ,结合临床资料分析该基因改变的临床意义。结果 宫颈癌中bcl - 2基因蛋白表达 (5 5 2 9% )显著高于宫颈正常和炎症组织 (18 75 % ) (P <0 0 1) ,其中 0期 (3/3)、Ⅰ期 (84 6 2 % )、Ⅱ期(74 5 1% )显著高于Ⅲ期 (2 8 5 7% ) (P <0 0 1)。bcl- 2蛋白表达与宫颈癌组织分化程度和存活率呈正相关。结论 bcl- 2基因的变化在宫颈癌发生和发展中起重要作用 ,其过度表达提示较好的临床行为和预后
Objective To investigate the changes of bcl-2 gene expression in human cervix and its clinical significance. Methods 149 cases of cervical tissue by immunohistochemical ABC method to detect the expression of bcl-2 gene protein, combined with clinical data analysis of the clinical significance of the gene change. Results The expression of bcl - 2 protein in cervical cancer was significantly higher than that in normal cervical tissue and cervical tissue (18 75%) (P <0.01), with stage 0 (3/3), stage Ⅰ ( 84 6 2%), and stage Ⅱ (74 5 1%) was significantly higher than that of stage Ⅲ (28 5 7%) (P 0 01). The expression of bcl-2 protein was positively correlated with the differentiation degree and survival rate of cervical cancer tissues. Conclusion The change of bcl-2 gene plays an important role in the occurrence and development of cervical cancer. The over-expression of bcl-2 gene suggests better clinical behavior and prognosis