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目的研究桑叶对小鼠的辅助降血糖功能。方法给予成年雌性小鼠四氧嘧啶(45mg/kg iV)建立高血糖模型。筛选高血糖模型动物40只(尾血血糖值在10～25mmol/L范围内)随机分4组,每组10只,以0.1、1.0、3.0g/(kg·d)设置剂量,灌胃量为0.02ml/(g·d),对照组给予同体积溶剂蒸馏水,连续灌胃30d后比较各组空腹血糖及糖耐量值。结果3.0g/(kg·d)剂量组桑叶咀嚼片对正常小鼠体重及空腹血糖值未见影响;1.0、3.0g/(kg·d)剂量组能明显降低四氧嘧啶高血糖模型小鼠空腹血糖值、升高其空腹血糖下降率并降低给予葡萄糖后0、0.5、2.0h的血糖曲线下面积,与对照组比较,差异均有统计学意义。结论桑叶具有辅助降血糖功能。
Objective To study the hypoglycemic function of mulberry leaves in mice. Methods Adult female mice were given alloxan (45 mg / kg iV) to establish a hyperglycemic model. Forty rabbits were randomly divided into 4 groups (10 mice in each group), 10 mice in each group. The dose was set at 0.1, 1.0 and 3.0 g / (kg · d) Was 0.02ml / (g · d), the control group was given the same volume of solvent distilled water, continuous gavage 30d after the comparison of fasting blood glucose and glucose tolerance values. Results No significant difference was observed in body weight and fasting blood glucose of 3.0g / (kg · d) dose group. The 1.0, 3.0g / (kg · d) dose group could significantly reduce the model of alloxan-induced hyperglycemia The fasting blood glucose level of rats increased the rate of fasting blood glucose and decreased the area under the blood glucose curve at 0, 0.5, and 2.0h after glucose administration. Compared with the control group, the differences were statistically significant. Conclusion Morus alba has hypoglycemic function.