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目的 探讨冠心病患者冠状动脉病变程度与C反应蛋白 (CRP)和白细胞介素 6(IL -6)的关系及经皮冠状动脉介入治疗 (PCI)后的变化。方法 采用酶联免疫吸附试验 (ELISA)测定经冠状动脉造影 (CAG)确诊的 3 6例冠心病并行PCI术的患者及 15例CAG正常者的血清CRP、IL -6水平 ,并比较不同冠脉病变程度者其血清值及PCI术后的变化。结果 血清CRP、IL -6水平显示 :冠心病患者明显高于正常对照组 ,三支病变组高于双支病变组 ,双支病变组高于单支病变组 ,PCI术后显著高于术前。CRP、IL -6之间呈正相关。结论 血清CRP、IL -6水平与冠心病冠脉病变程度关系密切 ,在冠状动脉粥样硬化的过程中有炎症反应参与 ,且在PCI术后应加强干预
Objective To investigate the relationship between coronary artery lesions and C-reactive protein (CRP) and interleukin-6 (IL-6) and the changes after percutaneous coronary intervention (PCI) in patients with coronary heart disease. Methods Serum levels of CRP and IL-6 in 36 patients with coronary artery disease and 15 normal subjects with coronary artery disease confirmed by coronary angiography (CAG) were measured by enzyme-linked immunosorbent assay (ELISA) The severity of the changes in serum values and postoperative PCI. Results Serum levels of CRP and IL-6 showed that the patients with coronary heart disease were significantly higher than those of the normal control group, the three lesions were higher than the double-vessel disease group, the double-vessel disease group was higher than the single vessel disease group, . CRP, IL -6 was positively correlated. Conclusions Serum levels of CRP and IL - 6 are closely related to the degree of coronary artery disease in patients with coronary artery disease. They are involved in the inflammatory response in the process of coronary atherosclerosis. Intervention should be intensified after PCI