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早在1909年Wolboch就报道了慢性射线皮炎组织内出现不典型成纤维细胞。最近Fajordo等综合报道了X射线对于皮肤的影响。他们详细描述了X射线损伤的皮肤出现不典型成纤维细胞的组织形态。这种细胞核大而不规则且染色过深,有凝块的染色质,罕有核丝分裂。胞浆嗜碱性,受累细胞的核质内一般有2个以上的锥形凸出。细胞浆的嗜碱染色在电镜下证明是由于粗的内胞浆网增生的结
As early as 1909, Wolboch reported the appearance of atypical fibroblasts in chronic radiographic dermatitis. Recently, Fajordo et al. comprehensively reported the effects of X-rays on the skin. They described in detail the appearance of atypical fibroblasts in x-ray-damaged skin. The nuclei are large and irregular and stained too deep, with clot chromatin and rare nuclear fission. The cytoplasm is basophilic, and the nucleus of affected cells generally has two or more conical projections. Alkaline staining of the cytoplasm was confirmed by electron microscopy as a result of thick intercellular cytoplasmic proliferation