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研究了丹参酚酸类对EDTA-H2O2-Fe2+和VitC-H2O2-Fe2+系统中水杨酸的羟基化作用。在后一体系中,这类化合物剂量依赖性地抑制羟化作用,其作用强度和抗脂质过氧化基本一致。而在前一体系中,作用较复杂。大多数丹参酚酸类剂量依赖性地抑制水杨酸羟化作用,但丹参酚酸A作用例外─和VitC作用相似,丹参酚酸A在低剂量时促进水杨酸羟基化作用,而在高剂量时则抑制。这类化合物能与铁离子结合或络合,但其络合常数较EDTA-铁络合常数低二个数量级以上,因而认为丹参酚酸类化合物可能具有羟自由基捕捉作用。
Hydroxylation of salicylic acid in EDTA-H2O2-Fe2 + and VitC-H2O2-Fe2 + systems was studied by salvianolic acids. In the latter system, these compounds dose-dependently inhibit the hydroxylation, the intensity of its action and anti-lipid peroxidation are basically the same. In the former system, the role is more complex. Most of the salvianolic acids inhibit the hydroxylation of salicylic acid in a dose-dependent manner, except for the action of salvianolic acid A - similar to the action of VitC, salvianolic acid A promotes hydroxylation of salicylic acid at low doses, When the dose is inhibited. These compounds can bind or complex iron ions, but their complexation constants are more than two orders of magnitude lower than that of EDTA-iron complexes. Therefore, it is concluded that salvianolic acids may have hydroxyl radical catching effect.