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目的:探讨放射性微球在兔不同 器官中的分布。方法:将17Y2O3 19 AI2O3 64SiO2玻璃微球通过动脉导管注 入到兔的肝脏中,2h后将兔杀死,分别取 肺、肝、肾、脾、胃和十二指肠组织,用硝酸 溶解后测定微球的含量,部分肝脏组织用 HE染色后显微镜下观察。结果:不同质 量及直径的玻璃微球在肝脏组织中都分布 均匀,紧密地栓塞肝动脉的末端,而且研究 发现直径≤20μm或质量≥15mg的玻璃 微球均可以漂移至肺、脾、肾等重要脏器, 但是没有发现质量10mg直径20～30μm 的微球漂移现象。结论:新型玻璃微球 17Y2O3 19AI2O3 64SiO2均匀分布于直径 为20～30μm的肝微小动脉中,而且质量 直径适中的玻璃微球没有血液漂移现象, 能够达到临床的需要。
Objective: To investigate the distribution of radioactive microspheres in different organs of rabbits. METHODS: 17Y2O3 19 AI2O3 64SiO2 glass microspheres were injected into the liver of rabbits through the arterial catheter. After 2 hours, the rabbits were sacrificed and lung, liver, kidney, spleen, stomach and duodenum tissues were taken out and dissolved in nitric acid Microspheres content, part of the liver tissue was stained with HE microscopically observed. Results: The glass microspheres with different mass and diameter were uniformly distributed in the liver tissues and embolized the ends of the hepatic artery tightly. Moreover, it was found that the glass microspheres with diameter ≤20μm or mass ≥15mg can all migrate to lung, spleen and kidney Important organ, but did not find the quality of 10mg diameter 20 ~ 30μm microsphere drift phenomenon. CONCLUSION: The new glass microspheres 17Y2O3 19AI2O3 64SiO2 are evenly distributed in the hepatic arterioles 20 ~ 30 μm in diameter. The glass microspheres with medium diameter and medium diameter have no blood drifting, which can meet the clinical needs.