蛋白酪氨酸磷酸酶(PTP)是酪氨酸磷酸化作用依赖的细胞信号关键调节剂。PTP 活性受到干扰就会导致多种疾病,如:免疫系统疾病、癌症、神经疾病、感染性疾病、糖尿病、骨质疏松、肥胖症等发生。PTP1B 从生理和病理角度参与胰岛素受体信号的调节。缺乏 PTP1B 的小鼠对胰岛素的敏感性增强; Protein tyrosine phosphatase (PTP) is a key regulator of tyrosine phosphorylation-dependent cellular signaling. The disturbance of PTP activity leads to various diseases such as: immune system diseases, cancers, neurological diseases, infectious diseases, diabetes, osteoporosis, obesity and the like. PTP1B is involved in the regulation of insulin receptor signaling both physiologically and pathologically. Mice lacking PTP1B have increased insulin sensitivity;