利用聚乙烯醇和阿拉伯胶作为修饰剂,采用溶剂挥发法制备聚乳酸微球,通过正交实验设计研究了不同的修饰剂、有机溶剂、聚乳酸浓度、表面活性剂、搅拌速度等因素对微球粒径的影响,并对制备的微球粉体学性质进行了初步研究.结果表明,在本文的工艺流程下制备的微球具有较均一的粒径,平均粒径为2.0~3.0μm,微球表面平滑,呈球形. The polylactic acid microspheres were prepared by solvent evaporation method using polyvinyl alcohol and gum arabic as modifiers. The effect of different modifiers, organic solvents, concentration of polylactic acid, surfactant and stirring speed on the microspheres Particle size and the microstructure of the microspheres prepared preliminary results show that the microspheres prepared in this article process has a more uniform particle size, the average particle size of 2.0 ~ 3.0μm, micro The ball surface is smooth, spherical.