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目的:观察参麦注射液对慢性阻塞性肺疾病急性加重期(AECOPD)患者外周血白细胞、C反应蛋白(CRP)、前降钙素原(PCT)的影响。方法:将2012年8月至2013年8月本科收治的68例AECOPD患者作为研究对象,其中治疗组34例、对照组34例。对照组采用平喘、吸氧、雾化吸入、呼吸功能锻炼,抗感染治疗等:治疗组在此基础上加用参麦注射液,疗程为7 d。入院1 d和治疗7 d时测定外周血白细胞、CRP、PCT。结果:两组治疗后外周血白细胞、PCT、CRP水平均较治疗前降低(P<0.05),但治疗组治疗后上述指标较对照组降低更加明显(P<0.05)。结论:参麦注射液能显著降低AECOPD患者的炎症反应,是辅助治疗的理想药物之一。
Objective: To observe the effect of Shenmai injection on peripheral blood leukocytes, C-reactive protein (CRP) and procalcitonin (PCT) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 68 AECOPD patients admitted to our hospital from August 2012 to August 2013 were selected as study subjects, including 34 in the treatment group and 34 in the control group. The control group used asthma, oxygen inhalation, inhalation, respiratory function, anti-infective treatment: the treatment group on this basis with Shenmai injection, treatment for 7 days. Peripheral blood leucocytes, CRP and PCT were measured at 1 day and 7 days after treatment. Results: The levels of peripheral blood leukocytes, PCT and CRP in both groups were significantly lower than those before treatment (P <0.05). However, the above indexes were lower in the treatment group than those in the control group (P <0.05). Conclusion: Shenmai injection can significantly reduce the inflammatory response in AECOPD patients and is one of the ideal drugs for adjuvant therapy.