目的分析CoxA16或EV71病毒致手足口病患儿外周血中T细胞亚群变化,探讨可能发病机制。方法采用流式细胞仪检测T细胞亚群。结果 CoxA16和EV71感染患儿T细胞各亚群百分率均低于对照组,且EV71组低于CoxA16组;CoxA16和EV71普通型间比较,差异无统计学意义(P>0.05);重度型间比较,EV71重度型CD3+、CD4+和CD8+百分率低于CoxA16重度型,两种病毒重度感染型T细胞各亚群分别低于普通型。结论 CoxA16和EV71感染引发机体T淋巴细胞免疫功能降低可能与其致病机制有关。 Objective To analyze the changes of T cell subsets in peripheral blood of children with hand-foot-mouth disease induced by CoxA16 or EV71 and to explore the possible pathogenesis. Methods T cell subsets were detected by flow cytometry. Results The percentages of T lymphocyte subsets in children with CoxA16 and EV71 infection were lower than those in the control group and lower in the EV71 group than in the CoxA16 group. There was no significant difference between the CoxA16 and EV71 common types (P> 0.05) The percentages of severe CD3 +, CD4 +, and CD8 + in EV71 were lower than those in CoxA16 severe subtype. Conclusion The decreased immune function of T lymphocytes induced by CoxA16 and EV71 may be related to the pathogenesis.