接头蛋白 (adapter proteins)是一类既无激酶活性 ,也无转录因子活性 ,但可介导信号蛋白分子之间或信号蛋白与脂类分子间相互作用的蛋白分子。在抗原受体启动的淋巴细胞活化信号传导途径中 ,接头蛋白分子发挥着重要的衔接和调节作用。本文介绍与 T细胞活化相关的 L AT、SL P- 76和 Gads,与 B细胞活化相关的 BL NK与 MAPK途径相关的 Grb2、Shc、Sos和 Vav分子 ,及具有负性调节作用的 Cb1等接头蛋白分子近年来的研究进展 Adapter proteins are a class of protein molecules that have neither kinase activity nor transcription factor activity but that mediate the interaction between signaling protein molecules or signaling proteins and lipid molecules. In the antigen receptor-activated lymphocyte activation signaling pathway, linker protein molecules play an important role in convergence and regulation. In this review, we present LAT, SL P-76 and Gads related to T cell activation, Grb2, Shc, Sos and Vav molecules associated with MAPK pathway and BL NKs associated with B cell activation, and Cb1 and other linkers with negative regulatory effects Research progress of protein molecules in recent years