作者对接触苯(65人,苯组)、甲苯(35人,甲苯组)、以及苯和甲苯的混合物(55人,混合组)的3组男性工人,测定各组在上班期接触物质的浓度和班末期尿中代谢物的含量。另外,为了确定本底水平,a!-对35名不接触毒物的男性工人(对照组)进行了尿中同样代谢物的测定。当三个接触组的每一组与对照组进行计算分析时,i组接触溶剂的浓度与尿中相应的代谢物(即来源于苯的酚、邻苯二酚和醒醇,以及来源于甲苯的马尿酸和邻甲酚)呈直线关系。结台回归分析的回归线比较,发现混合组尿醇(但无邻苯二酚)的含量比苯组低。对接触各种不同i}度的苯进行比较时,表明由于同时接触甲苯,苯在人体内生物转化为酚化合物(除邻苯二酚)被抑制。反之,甲苯的代谢产物马尿酸由于同时接触到苯也被抑制了。甲苯到邻甲酚的转化也由于苯的存在而 The authors tested three groups of male workers exposed to benzene (65, benzene), toluene (35, toluene), and a mixture of benzene and toluene (55, mixed group) And the end of the class urine metabolites content. In addition, in order to determine the background level, the same metabolite in urine was tested in 35 non-contact male workers (control group). When calculated for each of the three exposure groups and the control group, the concentrations of the solvent exposed in group i to the corresponding metabolites in the urine (ie, phenol, catechol, and resorcinol derived from benzene, as well as those derived from toluene Of hippuric acid and o-cresol) showed a linear relationship. Conclusions regression line regression analysis showed that the mixed group of urinary alcohol (but no catechol) content lower than the benzene group. Comparisons of benzene with various degrees of benzene showed that benzene was inhibited from being converted to a phenolic compound (except catechol) in the human body due to simultaneous exposure to toluene. Conversely, hippurate, a metabolite of toluene, was also inhibited by simultaneous exposure to benzene. The conversion of toluene to o-cresol is also due to the presence of benzene