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目的 探讨A族溶血性链球菌感染在抽动障碍发病中的作用。方法 采用抗DNA酶B微量法 ,测定 4 6例抽动障碍患者和 4 6名健康对照的抗DNA酶B抗体。结果 抽动障碍患者抗DNA酶B的几何平均滴度 ( 0 19U/L)高于健康对照 ( 0 12U/L ;t=2 17,P <0 0 5 ) ;抗DNA酶B的阳性率 ( 5 2 % ,2 4 / 4 6 )也高于健康对照组 ( 30 % ,14 / 4 6 ) ,差异有显著性 ( χ2 =4 4 8,OR =2 4 9,P <0 0 5 )。抽动障碍患者抗DNA酶B滴度与耶鲁抽动症整体严重度量表评分间呈正相关 (r=0 35 ,P <0 0 5 )。结论 A族溶血性链球菌感染可能与抽动障碍发病有关
Objective To investigate the role of hemolytic streptococcus infection in the pathogenesis of tic disorder. Methods Anti-DNase B anti-DNase B antibody was detected in 46 patients with tic disorder and 46 normal controls. Results The geometric mean titers of DNase B (0 19 U / L) in patients with tic disorder were significantly higher than those in healthy controls (0 12 U / L; t = 2 17, P 0 05) 2%, 24/46) were also higher than those in healthy controls (30%, 14/46) (χ2 = 448, OR = 299, P <0 05). There was a positive correlation between titers of DNase B titers and the overall severity scale of Yale Tourette (r = 0 35, P <0 05). Conclusion A group of hemolytic streptococcus infection may be related to the incidence of tic disorder