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目的 了解妊娠期妇女血浆内皮素 (ET)、血栓素 (TXA2 )、前列环素 (PGI2 )、心钠素 (ANP)含量变化 ,探讨其与妊高征的关系。方法 采用放免法 ,在妊娠早、中、晚期及产后序贯测定血浆ET、TXA2 、PGI2 和ANP含量。正常妊娠142例 ,妊高征 36例 ,与非妊娠妇女 30例对照。结果 正常妊娠中期ET明显下降 (P <0 0 5 ) ,TXA2 、PGI2 、ANP含量与对照组无明显差异。妊娠晚期四项参数含量显著高于对照组 (P <0 0 1)。ET/ANP和TXA2 /PGI2 比值无显著变化。妊高征中期ET、TXA2 明显高于正常妊娠组 (P <0 0 1,P<0 0 5 )。ET/ANP ,TXA2 /PGI2 比值明显增高。妊高征妊娠晚期 ,除PGI2 外 ,其它三项参数及ET/ANP ,TXA2 /PGI2 比值均高于正常妊娠组 (P <0 0 1,P <0 0 5 )。结论 ET ,TXA2 含量及ET/ANP ,TXA2 /PGI2 比值升高与妊高征发病密切相关 ,比值增高幅度与病情严重程度成正比。
Objective To investigate the changes of plasma endothelin (ET), thromboxane (TXA2), prostacyclin (PGI2) and atrial natriuretic peptide (ANP) in pregnant women and to explore their relationship with PIH. Methods The levels of plasma ET, TXA2, PGI2 and ANP were determined by radioimmunoassay in the early, middle, late and postpartum period. 142 cases of normal pregnancy, PIH 36 cases, compared with 30 non-pregnant women control. Results The ET in the middle of normal pregnancy decreased significantly (P <0 05), and the levels of TXA2, PGI2 and ANP in the control group were not significantly different. The contents of four parameters in late pregnancy were significantly higher than those in control group (P <0.01). There was no significant change in the ET / ANP and TXA2 / PGI2 ratios. The levels of ET and TXA2 in the middle stage of PIH were significantly higher than those in the normal pregnancy group (P <0.01, P <0.05). ET / ANP, TXA2 / PGI2 ratio was significantly higher. In the third trimester of pregnancy-induced hypertension, except for PGI2, the other three parameters and the ratio of ET / ANP and TXA2 / PGI2 were higher than those of normal pregnancy (P <0.01, P <0.05). Conclusion The increase of ET, TXA2, ET / ANP, TXA2 / PGI2 ratio is closely related to the pathogenesis of PIH. The rate of increase is proportional to the severity of the disease.