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目的 :探讨我国汉族COPD患者ABO血型分布α1-AT含量 ,以及ABO血型与COPD、α1-AT含量间的关系。方法 :采用常规玻片法测定 6 11名汉族健康者及 2 0 0名COPD患者的ABO血型 ;单相免疫扩散法测定了其中 180名COPD患者的α1-AT含量。用Bernstein法及其较正公式计算ABO血型基因频率 ,woolf统计法计算相对发病率。结果 :健康者与COPD组间ABO血型构成特征均为B >O >A >AB ,两组的基因频率分别为P =0 .1912 ;0 .1886 q =0 .2 371;0 .2 6 99r =0 .5 717;0 .5 4 15 ;两组ABO血型分布均符合Hardy -Wemberg平衡法则。A/O和B/O的相对发病率分别为 1.0 993和 1.2 897(P >0 .0 5 ) ;A、B、O、AB四种血型COPD的相对危险率分别为 0 .95 5 7、1.2 14 9、0 .8314、1.0 4 13(P均 >0 .0 5 ) ;不同血型的COPD患者的α1-AT含量无差异 (P >0 .0 5 )。结论 :本组COPD患者中ABO血型抗原与COPD的发病无明显关联 ,这与国外某些学者报道的COPD患者以A型血为多的结果不同 ,其原因可能为 :种族差异 ;样本量少所致。本组COPD不同血型间的α1-AT含量无差异。因此 ,在我国ABO抗原与COPD发病及ABO血型与α1-AT含量的确切关系有待进一步探讨。
Objective: To investigate the distribution of ABO blood group α1-AT and the relationship between ABO blood group and COPD, α1-AT content in COPD patients of Han nationality in our country. Methods: ABO blood samples were obtained from 6,11 healthy controls and 200 COPD patients by routine slide method. Α1-AT levels were measured in 180 COPD patients by single-phase immunodiffusion assay. The frequency of ABO blood group gene was calculated by Bernstein method and its more correct formula, and the relative incidence was calculated by woolf statistical method. Results: The constitutional characteristics of ABO blood group were B> O> A> AB between healthy controls and COPD patients, and the frequencies of the two groups were P = 0.1912; 0.1886 q = 0.271; 0.2699r = 0 .5 717; 0 .5 4 15; ABO blood group distribution in both groups are in line with the Hardy-Wemberg balance rule. The relative rates of A / O and B / O were 1.0 993 and 1.2 897, respectively (P> 0.05). The relative risk rates of COPD in A, B, O and AB were 0.957, 1.2 14 9,0. 8314,1.0 4 13 (P all> 0.05). There was no difference in α1-AT content between COPD patients with different blood types (P> 0.05). Conclusion: There is no significant correlation between ABO blood group antigen and COPD in this group of patients with COPD. This may be due to the difference in the results of type A blood among COPD patients reported by some foreign scholars. The reasons may be as follows: racial differences; To This group of COPD different blood type α1-AT content was no difference. Therefore, in our country ABO antigen and the pathogenesis of COPD and the exact relationship between ABO blood type and α1-AT needs to be further explored.