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本文根据H_2受体拮抗剂作用原理及药物体内吸收、代谢规律,设计并合成了九个结构类似的胍基噻唑类化合物,经实步药理实验表明,化合物C-173和C-174对组胺H_2受体的拮抗作用较强,有必要进一步研究。
In this paper, nine structurally similar guanidinothiazoles have been designed and synthesized according to the action principle of H 2 receptor antagonists and the absorption and metabolism of drugs in vivo. The pharmacological experiments show that compounds C-173 and C-174 are effective for histamine H 2 receptor antagonism stronger, it is necessary to further study.