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关于肝素与葡萄糖注射液、葡萄糖盐水注射液的配伍问题、文献已有记载.配伍结果很不一致、给临j床用药带来很大的顾虑.为此作者复习了大量的文献.做了有关的实验观察以及理论分析,综合临床经验.认为两药是可以配伍的从理论上分析肝素是一种粘多糖的硫酸酯.分子中含有40%硫酸根、使分子带有强大阴电荷、若水解移去硫酸根或中和阴荷、则肝素抗凝活性消失.肝素能影响凝血酶及凝血因子Ⅻ、Ⅺ、Ⅹ、Ⅸ等凝血过程的多个环节.其作用原理现已阐明.肝素进入循环后,首先与血浆中一种曾被称为肝素辅助因子的a_2球蛋白结合.这一单链.分子量为58000的球蛋白就是抗凝血酶皿、事实上肝素是作为抗凝血酶Ⅲ的辅助因子起作用的.抗凝血酶Ⅲ作为缓慢的生理性抗凝血物质、是一种抑制性酶,可使以丝氨酸为活性中心的蛋白质失去活性.肝素通过其酸性基与抗凝血酶Ⅲ的碱性残基
On the compatibility of heparin and glucose injection, glucose saline injection, the literature has been documented. The results are very inconsistent compatibility, clinical j bed brought great concern, for which the author reviewed a large number of documents. Experimental observation and theoretical analysis, combined clinical experience, that the two drugs can be compatible theoretically analyzed heparin is a mucopolysaccharide sulfate containing 40% sulfate, the molecule with a strong negative charge, if the hydrolysis Desulfated or neutralized negative, the heparin anticoagulant activity disappeared.Hp can affect the thrombin and coagulation factors Ⅻ, Ⅺ, Ⅹ, Ⅸ and many other aspects of the process of coagulation.Its role has been clarified.When heparin into the circulation , First with a plasma globulin known as heparin cofactor a_2 globulin. This single chain. The molecular weight of 58,000 globulin is anti-thrombin dish, in fact, heparin is as antithrombin Ⅲ auxiliary Factor acting antithrombin Ⅲ as a slow physiological anticoagulant substance is an inhibitory enzyme that can serine as the active center of protein inactivation of heparin by its acidic and anti-inflammatory Thrombin Ⅲ basic residues