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婴幼儿血管瘤(IH)是最常见的儿童期良性肿瘤,具有独特的增生和自发消退的自然病程,但发病机制仍未阐明,血管瘤的标志物也缺乏特异性。目前,组织学标志物主要包括血管生成、胎盘、凋亡、缺氧、炎症、淋巴、干细胞、周细胞、肥大细胞等相关标志物;体液标志物包含血清和尿液标志物,前者主要有雌激素和VEGF等细胞因子,后者主要有bFGF和MMP-2。但至今尚未发现与IH病程密切相关、特异度敏感度较强的血清标志物,本文就此方面的研究进展进行综述。
Infantile hemangiomas (IH) are the most common childhood benign tumors with a unique natural history of hyperplasia and spontaneous regression but the pathogenesis remains unclear and the markers of hemangiomas lack specificity. Currently, histological markers include angiogenesis, placenta, apoptosis, hypoxia, inflammation, lymphoid, stem cells, pericytes, mast cells and other related markers; body fluid markers include serum and urine markers, the former mainly female Hormones and VEGF and other cytokines, the latter mainly bFGF and MMP-2. However, no serum markers closely related to the course of IH and highly specific sensitivity have been found so far. This article reviews the progress of this research.