论文部分内容阅读
目的:探讨阴茎阴囊Paget病的临床特点和诊治方法,提高对阴茎阴囊Paget病的诊治水平。方法:对18例阴茎阴囊Paget病患者的临床资料进行回顾性分析,全部患者先行患处活检,后行术中快速冷冻切片辅助检查切缘的病灶根治性切除治疗,18例均未行预防性腹股沟浅组淋巴结清扫术。术后末行化疗或放疗。结果:术后18例患者均Ⅰ期愈合。随访6个月～7年,平均32个月。2例复发,均为真皮层受累患者。其中1例局部复发,接受再次手术治疗,至今存活;1例术后2年发现腹股沟区淋巴结转移,再次手术1年后由于肺转移死亡。1例因其他疾病死亡。结论:阴茎阴囊Paget病应尽早行皮肤活检确诊,该病的首选治疗方法为术中快速冷冻切片辅助检查切缘的病灶根治性手术切除,手术效果好,预后满意,对复发者可行二次手术。
Objective: To investigate the clinical features, diagnosis and treatment of Paget’s disease of the penile scrotum and improve the diagnosis and treatment of Paget’s disease. Methods: The clinical data of 18 patients with penile scrotum Paget were retrospectively analyzed. All the patients were biopsied first and followed by rapid intraoperative frozen section to assist in radical resection of the margins. None of the 18 patients received prophylactic groin Superficial lymph node dissection. Postoperative chemotherapy or radiotherapy. Results: All the 18 patients healed in the first stage. Follow-up 6 months to 7 years, an average of 32 months. 2 cases of recurrence, are involved in the dermis patients. One case of local recurrence, underwent reoperation, and survived to this day; one case of inguinal lymph node metastasis was found 2 years after operation, died of lung metastasis one year after the second operation. 1 patient died of other diseases. Conclusion: The penile scrotum Paget disease should be confirmed by skin biopsy as early as possible. The first choice of the disease is intraoperative rapid frozen section to assist the radical resection of the lesion. The operative effect is good and the prognosis is satisfactory. The second surgery .