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选择12～13岁小学生共235例，随机分为实验组和对照组，实验组用骨碎补、连翘口胶，对照组用齿必康含片，疗程二周，用药前后均测定口腔变形链球菌水平和牙菌斑指数。结果表明，实验组和对照组对口腔变形链球菌都具有明显的抑制作用（P＜0．01）。对牙菌斑的作用，骨碎补、连翘口胶组优于齿必康组（P＜0．05）。
A total of 235 primary school students aged 12 to 13 years were randomly divided into experimental group and control group. The experimental group was treated with Rhizoma Drynariae and Forsythia gum, and the control group was treated with Tebi Kang Lotion. The treatment period was two weeks, and the oral deformity was measured before and after the medication. Streptococcus level and plaque index. The results showed that the experimental group and the control group had significant inhibitory effect on oral Streptococcus mutans (P<0.01). The effect of Gushao supplement and Forsythia gum group on dental plaque was better than that of Toibi Kang group (P<0.05).