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为了解酒精摄入量与云锡 (YTC)矿工肺癌危险性的关系 ,在食物频率问卷 (FFQ)资料中饮酒重复性和有效性研究的基础上 ,计算出云锡矿工肺癌高危人群酒精摄入量 ;用 χ2 检验、单因素、多因素Cox回归分析了云锡矿工肺癌高危人群不同酒精摄入量与其发生肺癌相对危险性的关系。结果表明 :酒精摄入量与云锡矿工肺癌发病率呈“J形”关系 ,即不饮酒和中等量以上饮酒者 (酒精摄入量≥ 5 0 g/d) ,肺癌发病率显著高于少量饮酒 (酒精摄入量 0～ 5 0g/d) (P <0 0 1) ;少量饮酒与肺癌相对危险性呈负相关 (RR <1,P <0 0 5 ) :大量饮酒 (酒精摄入量≥ 10 0 g/d)与肺癌相对危险性呈正相关 (RR >1,P <0 0 1) ;经调整年龄、工龄、吸烟后 ,没有发现少量饮酒对矿工肺癌患者具有保护作用 ,酒精摄入量大于 5 0 g/d即显示与肺癌相对危险性呈正相关 (RR >1,P <0 0 1) ,说明饮酒可能是云锡矿工肺癌发生的危险因素 ,且可能与职业危险因素有协同作用
To understand the relationship between alcohol intake and the risk of lung cancer in YTC miners, based on the reproducibility and effectiveness of alcohol consumption in the FFQ data, alcohol intake was calculated for high-risk lung cancer among Yunxi miners. Quantitative; using χ2 test, single factor, multi-factor Cox regression analysis of the relationship between different alcohol intake and the relative risk of lung cancer in high-risk lung cancer in Yunnan tin miners. The results showed that the amount of alcohol intake was a “J-shaped” relationship with the incidence of lung cancer among Yunxi miners, that is, non-drinkers and moderate drinkers (alcohol intake ≥ 50 g/d), the incidence of lung cancer was significantly higher than a small amount Alcohol consumption (alcohol intake 0-50 g/d) (P < 0 01); A small amount of alcohol consumption was negatively correlated with the relative risk of lung cancer (RR <1, P <0 05): Heavy drinking (alcohol intake ≥ 10 0 g/d) was positively correlated with the relative risk of lung cancer (RR>1, P <0 01). After adjustment for age, length of service and smoking, no small amount of alcohol was found to protect miners with lung cancer. Alcohol intake A dose greater than 50 g/d showed a positive correlation with the relative risk of lung cancer (RR >1, P < 0 01), indicating that drinking may be a risk factor for lung cancer in Yunnan tin miners, and may have a synergistic effect with occupational risk factors.