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目的:探讨Isaacs综合征的发病机制、临床特征、诊断和治疗。方法:回顾性分析中国医科大学附属第一医院神经内科收治的1例Isaacs综合征患者的临床表现、辅助检查、治疗和预后,结合文献进行分析。结果:患者男性,71岁。主要表现为自发性肌肉颤搐,睡眠时症状不消失。肌电图可见颤搐电位和轻度运动神经传导速度减慢。卡马西平治疗后症状控制良好。结论:Isaacs综合征是一种自身免疫性疾病,病因尚不明确,肌肉颤搐及典型肌电图表现是诊断关键,卡马西平和苯妥英钠为首选治疗药物。
Objective: To investigate the pathogenesis, clinical features, diagnosis and treatment of Isaacs syndrome. Methods: A retrospective analysis of 1 case of Isaacs syndrome admitted to Department of Neurology, the First Affiliated Hospital of China Medical University was performed. The clinical manifestations, adjuvant examination, treatment and prognosis were analyzed retrospectively. Results: Male patient, 71 years old. Mainly for spontaneous muscle twitching, symptoms do not disappear when sleeping. EMG shows twitch potential and mild motor nerve conduction slowed down. The symptoms were well controlled after carbamazepine treatment. Conclusion: Isaacs syndrome is an autoimmune disease, the etiology is not clear, muscle twitching and typical EMG performance are the key points of diagnosis. Carbamazepine and phenytoin sodium are the preferred therapeutic agents.