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光气、双光气中毒后最早发生的病变是肺气肿。本文测量肺气量、肺密度并观察肺形态以定量地研究双光气引起的肺气肿,结果表明:双光气单独刺激上呼吸道不会引起肺气肿,动物的肺密度为0.70±0.04((?)±SD),与对照组(0.66±0.04)相差不显著,P>0.05;将双光气单独吸入下呼吸道后,动物出现肺气肿,肺密度为0.59±0.05,非常显著小于对照组,P<0.01;双光气同时作用于上、下呼吸道后,动物的肺气肿程度最重,肺密度为0.50±0.06,显著小于单独将双光气吸入下呼吸道组,P<0.05,这一结果在双光气病理损害的发病机制研究中的意义尚待进一步探究。
Phosgene, the first occurrence of diphtheria after the disease is emphysema. In this paper, measurement of lung volume, lung density and lung morphology observed in order to quantitatively study the double phosgene-induced emphysema, the results showed that: double phosgene alone to stimulate the upper respiratory tract does not cause emphysema, animal lung density was 0.70 ± 0.04 ( (± SD), which was not significantly different from that of the control group (0.66 ± 0.04) (P> 0.05). After inhaling double phosgene into the lower respiratory tract alone, the animals developed emphysema with a lung density of 0.59 ± 0.05, Group, P <0.01. After the phosgene was applied to the upper and lower respiratory tract at the same time, the degree of emphysema in the animals was the highest. The lung density was 0.50 ± 0.06, The significance of this result in the pathogenesis of bi-phosgene remains to be further explored.