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目的研究黄皮叶对链脲佐菌素(STZ)诱导的糖尿病模型大鼠的降血糖作用及其机制。方法大鼠随机分6组,即正常对照组,模型组,黄皮叶高、中、低剂量组及格列本脲组。除正常对照组外,其余各组大鼠腹腔注射STZ复制2型糖尿病模型,分别给予溶媒、黄皮叶及格列本脲进行干预,观察黄皮叶对2型糖尿病大鼠空腹血糖值(FBG)、葡萄糖耐受量、血清胰岛素水平、血脂指标、氧化应激的影响以及胰腺的病理变化。结果黄皮叶可明显降低2型糖尿病模型大鼠FBG水平,提高口服葡萄糖的耐受性,提高胰岛素水平,降低血脂的含量,同时能升高模型大鼠血清中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽(GSH)活性并降低丙二醛(MDA)、一氧化氮(NO)的含量,缓解胰腺病理变化。结论黄皮叶具有降糖调脂作用,可能与其促胰岛素分泌和抗氧化作用有关。
Objective To study the hypoglycemic effect of Huangpiye on streptozotocin (STZ) -induced diabetic rats and its mechanism. Methods The rats were randomly divided into 6 groups, namely normal control group, model group, Huangpiye high, medium and low dose group and glibenclamide group. Except for the normal control group, the rats in other groups were given intraperitoneal injection of STZ to induce type 2 diabetes mellitus. The rats were administered vehicle, yellow leaf and glibenclamide respectively to observe the effects of yellow leaves on fasting blood glucose (FBG) , Glucose tolerance, serum insulin, blood lipid, oxidative stress and the pathological changes of the pancreas. Results Huangpiye could significantly decrease the level of FBG in type 2 diabetes mellitus rats, increase the tolerance of oral glucose, increase the level of insulin, decrease the content of lipids, and increase the level of serum superoxide dismutase (SOD) Catalase (CAT) and glutathione (GSH) activity and reduce the content of malondialdehyde (MDA), nitric oxide (NO), alleviate the pathological changes of the pancreas. Conclusion Huangpi has hypoglycemic and lipid-lowering effects, which may be related to insulin secretion and antioxidation.