文献复习中,作者发现对化疗是否有效,是识别长期生存的多发性骨髓瘤(MM)患者的最重要因素。本研究不包括以下患者:孤立或多处的孤立性浆细胞瘤、髓外浆细胞瘤、浆细胞性白血病,特发性凝溶(本-周氏)蛋白尿,或以后可发展为症状性MM的、意义不明的单克隆丙种球蛋白病,对结缔组织病产生的浆细胞反应,肝病、转移癌或慢性感染。用醋酸纤维膜作血清蛋白电泳和Ponceaus染色。用对IgG、IgM、IgA,κ及L链有单一特异性的抗血清作免疫电泳。所有血清标本用Ouchterlony免疫扩散法来检测过多的IgD及IgE。用免疫扩散板或比浊计检测Ig量。对经过超滤的浓缩尿作电泳和免疫电泳. In reviewing the literature, the authors found that whether chemotherapy was effective or not was the most important factor in the identification of long-lived multiple myeloma (MM) patients. The following patients were excluded from this study: solitary or multiple solitary plasmacytoma, extramedullary plasmacytoma, plasmacytic leukemia, idiopathic coagulation (Ben-Zhou’s) albuminuria or later may develop symptomatic MM, unidentified monoclonal gammopathy, plasma cell response to connective tissue disease, liver disease, metastatic cancer, or chronic infection. Acetate membrane was used for serum protein electrophoresis and Ponceaus staining. Immuno-electrophoresis was performed using a single specific antisera to IgG, IgM, IgA, K and L chains. All serum samples were tested for excess IgD and IgE using the Ouchterlony immunodiffusion method. Use immunodiffusion plates or turbidimeters to measure the amount of Ig. Ultrafiltration concentrated urine for electrophoresis and immunoelectrophoresis.