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目的了解深圳市不同职业妇女人乳头瘤病毒(HPV)感染现状及其子宫颈上皮内瘤变(CIN)现患率。方法调查深圳市5种职业人群的HPV感染现状及CIN现患率,其中中小学教师130人、外来劳务工385人、服务业从业人员316人、特困下岗职工199人、医务人员420人,并以自然人群——某社区居民595人为对照,共计调查2045名妇女。采用hc2法检测高危型HPV (HPV-HR),联合超柏氏薄层液基细胞学(LCT)进行子宫颈癌与癌前病变的筛查,凡筛查HR-HPV阳性并LCT≥ASCUS及/或LCT≥LSIL,均经阴道镜下活检病理检查确诊CIN。结果(1)不同职业妇女HR-HPV感染率不同,服务业从业人员感染率最高(19.3%),医务人员的感染率最低(11.9%),服务业从业人员感染率明显高于医务人员、外来劳务工及居民,差异有统计学意义(P<0.05)。(2)在2045例妇女中,共发现HPV感染所致子宫颈病变199例,其中组织学可见HPV感染改变、CIN1～3及子宫颈癌的发病率分别为4.11%、3.28%、1.67%、0.54%和0.15%,随着子宫颈病变程度的加重,其发病率逐渐降低。(3)不同职业妇女的不同程度CIN现患率明显不同,服务业从业人员HSIL发病率最高,而中小学教师的HSIL发病率最低。结论深圳市不同职业人群的HR-HPV感染率及CIN现患率不同。服务业从业人员的HR-HPV感染率及HSIL发病率最高。
Objective To investigate the status of human papillomavirus (HPV) infection and the prevalence of cervical intraepithelial neoplasia (CIN) among different occupational women in Shenzhen. Methods The prevalence of HPV infection and prevalence of CIN in 5 occupational groups in Shenzhen were investigated. Among them, 130 were primary and secondary school teachers, 385 were migrant workers, 316 were service workers, 199 were laid-off workers and 420 were medical workers. Natural population - a community of 595 people as a control, a total of 2045 women surveyed. High-risk HPV (HPV-HR), combined with ultra-thin liquid-based cytology (LCT) hc2 detection of cervical cancer and precancerous lesions screening, screening for HR-HPV positive and LCT ≥ ASCUS and / Or LCT ≥ LSIL, were confirmed by colposcopic biopsy biopsy CIN. Results (1) The infection rates of HR-HPV in different occupations were different. The infection rate of service workers was highest (19.3%) and that of medical workers was the lowest (11.9%). The infection rate of service workers was significantly higher than that of medical workers Labor workers and residents, the difference was statistically significant (P <0.05). (2) Among 2045 women, 199 cases of cervical lesions caused by HPV infection were found. Histological examination showed that HPV infection was changed. The incidence of CIN1 ~ 3 and cervical cancer were 4.11%, 3.28% and 1.67%, respectively. 0.54% and 0.15%, with the severity of cervical lesions, the incidence gradually decreased. (3) The prevalence of CIN in different occupational groups was significantly different among different occupational groups. The incidence of HSIL among service practitioners was the highest, while the incidence of HSIL among primary and secondary school teachers was the lowest. Conclusion The prevalence of HR-HPV infection and CIN in different occupational groups in Shenzhen are different. The incidence of HR-HPV infection and HSIL among service workers was the highest.