目的:观察黄芩甙锌(HBZn)对冰醋酸致大鼠胃溃疡保护作用。方法:采用Okzbe冰醋酸法改进后建实验性胃溃疡模型,随机分为8组:假手术组、模型组、黄芩甙(HB)组(0.35mg/kg)、葡萄糖酸锌组(0.07mg/kg)、奥美拉唑组(4.00mg/kg)、HBZn低、中、高剂量组(0.013、0.025、0.05mg/kg)。体式显微镜下计算溃疡面积;比色法测定血浆丙二醛(MDA)、一氧化氮(NO)含量;透射电镜显微技术电镜观察给药后各组胃黏膜组织形态学变化。结果:与模型组比较,HBZn低、中、高剂量组可减少溃疡面积(P<0.05),降低血浆中MDA水平,升高NO水平(P<0.05),HBZn高剂量组与奥美拉唑作用相当,且明显优于HB组和葡萄糖酸锌组(P<0.05)。同时HBZn可改善胃黏膜坏死、炎细胞浸润、组织水肿及线粒体损伤。HB组和葡萄糖酸锌组作用不如HBZn低、中、高剂量组。结论:HBZn对冰醋酸所致大鼠胃黏膜溃疡具有保护作用,该作用可能与抑制炎性反应、拮抗氧化应激、保护线粒体结构功能有关。 Objective: To observe the protective effect of baicalin zinc (HBZn) on gastric ulcer induced by acetic acid in rats. Methods: Experimental gastric ulcer model was established by Okzbe acetic acid method and divided into 8 groups at random: sham group, model group, HB group (0.35mg / kg), zinc gluconate group (0.07mg / kg), omeprazole group (4.00mg / kg), HBZn low, middle and high dose group (0.013,0.025,0.05mg / kg). The area of ​​ulcer was calculated under stereomicroscope. The contents of plasma malondialdehyde (MDA) and nitric oxide (NO) were measured by colorimetric method. The morphological changes of gastric mucosa were observed by transmission electron microscopy and electron microscopy. Results: Compared with model group, HBZn low, medium and high dose groups could reduce ulcer area (P <0.05), decrease plasma MDA level and increase NO level (P <0.05). HBZn high dose group and omeprazole The effect is quite, and obviously superior to the HB group and the zinc gluconate group (P <0.05). At the same time HBZn can improve gastric mucosal necrosis, inflammatory cell infiltration, tissue edema and mitochondrial damage. HB group and zinc gluconate group than HBZn low, medium and high dose group. Conclusion: HBZn has a protective effect on glaucoma-induced gastric mucosal ulcer in rats, which may be related to inhibiting inflammatory reaction, antagonizing oxidative stress and protecting mitochondrial structure and function.