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AIM: The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil(PLFO) in rabbits following a hyperlipidemic diet. METHOD: Twenty healthy female(WNZ) rabbits were divided into four groups of five animals each:(a) normal control(NC group) receiving standard diet,(b) hyperlipidemic control(EY) group receiving standard diet and gavaged daily with egg yolk(10 mL),(c) hyperlipidemic + PLFO(EY + PLFO) group receiving as the EY group and treated daily with PLFO(2 mL/kg BW,(d) hyperlipidemic + simvastatin(EY + SVS) group receiving as the EY group and treated once daily with 2.5 mg/kg BW of simvastatin. At the end of the six-week experimental period, the lipidemic profiles of the different groups were investigated. RESULTS: In the EY group, the egg yolk resulted in a significant increase of total cholesterol(TC), triglycerides(TG), HDL-C, LDL-C, and the LDL-C/HDL-C ratio. Both the EY + PLFO and EY + SVS groups, when compared to the EY group, showed a significant decrease of TC, TG, LDL-C, and the LDL-C/HDL-C ratio. However, with respect to HDL-C the differences were not significant. The TGs were significantly lower(P < 0.001) in the simvastatin-treated group when compared to rabbits treated in the PLFO group. CONCLUSION: The study concludes that P. lentiscus fatty oil(PLFO) possesses anti-hyperlipidemic properties at least in reducing total cholesterol, LDL-cholesterol and triglycerides.
AIM: The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet. METHOD: Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) (b) hyperlipidemic control (EY) group receiving standard diet and gavaged daily with egg yolk (10 mL), (c) hyperlipidemic + PLFO (EY + PLFO) group receiving as the EY group and treated daily with PLFO (2 mL / kg BW, (d) hyperlipidemic + simvastatin (EY + SVS) group receiving as the EY group and treated once daily with 2.5 mg / kg BW of simvastatin. At the end of the six-week RESULTS: In the EY group, the egg yolk resulted in a significant increase of total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, and the LDL-C / HDL-C ratio. Both the EY + PLFO and EY + SVS groups, when compared to the EY group, showed a Significantly lower TC, TG, LDL-C, and the LDL-C / HDL-C ratio. However, with respect to HDL-C the differences were not significant. The TGs were significantly lower (P <0.001) treated group when compared to rabbits treated in the PLFO group. CONCLUSION: The study concludes that P. lentiscus fatty oil (PLFO) possesses anti-hyperlipidemic properties at least in reducing total cholesterol, LDL-cholesterol and triglycerides.