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研究硫化砷(As2S2)对K562细胞凋亡的诱导作用。采用K562细胞体外培养,应用流式细胞仪(FCM)分析细胞周期,鉴定凋亡细胞,检测线粒体膜蛋白Apo27的表达。结果显示:As2S2能够诱导K562细胞凋亡,使细胞周期中的S期细胞减少,G2/M期细胞升高,提示:As2S2具有促凋亡效应
To study the induction effect of As2S2 on the apoptosis of K562 cells. The K562 cells were cultured in vitro, and the cell cycle was analyzed by flow cytometry (FCM). Apoptotic cells were identified and the expression of mitochondrial membrane protein Apo2.7 was detected. The results showed that As2S2 could induce the apoptosis of K562 cells, decrease the number of S phase cells and G2 / M phase cells in the cell cycle, suggesting that As2S2 has a pro-apoptotic effect