30例系统性红斑狼疮活动期眼底改变的发生率为46．66％；以静脉扩张纤曲、视网膜渗出物的发生率较高，视乳头改变和视网膜出血次之，动静脉交叉压迹和黄斑中心光反射消失较低；影响眼底改变的临床因素以浆膜炎、活动性肾损害及大脑狼疮为突出，血液异常则以高丙球蛋白血症、LE细胞（＋）、血红蛋白和血小板降低对眼底改变的影响更为明显。 The incidence of fundus changes in 30 patients with systemic lupus erythematosus was 46.66%. The incidence of retinal exudate was higher in patients with venous dilatation and fibrosis, followed by optic nerve head changes and retinal hemorrhage, arteriovenous cross indentation and The macular center light reflection disappears lower; the clinical factors that affect the fundus changes to serositis, active kidney damage and cerebral lupus prominent, abnormal blood is hyperbaric globulin, LE cells (), hemoglobin and platelet decreased fundus The impact of change is even more pronounced.