用平衡透析法研究了生理条件（ｐＨ７．４３）下Ｃｕ（Ⅱ）与人血清白蛋白（ＨＳＡ）或牛血清白蛋白（ＢＳＡ）的相互作用．结果表明，ＨＳＡ对Ｃｕ（Ⅱ）有１个强结合部位和９个弱结合部位，结合常数分别为１１×１０５及９１×１０２；ＢＳＡ对Ｃｕ（Ⅱ）有１个强结合部位和７个弱结合部位，结合常数分别为８４×１０４和７５×１０２．Ｈｉｌ常数表明Ｃｕ（Ⅱ）与ＨＳＡ或ＢＳＡ的结合均具有部分正协同效应 The interaction of Cu (Ⅱ) with human serum albumin (HSA) or bovine serum albumin (BSA) under physiological conditions (pH7.43) was studied by equilibrium dialysis. The results showed that HSA had one strong binding site and nine weak binding sites for Cu (Ⅱ) with a binding constant of 11 × 105 and 91 × 102, respectively. BSA had a strong binding site to Cu (Ⅱ) And seven weakly binding sites with binding constants of 84 × 104 and 75 × 102, respectively. Hil constant indicates that Cu (Ⅱ) has some positive synergistic effect with HSA or BSA